Endocrine Abstracts

Background/Aims: Food intake is orchestrated by complex neuronal networksresiding in the forebrain, hypothalamus, and brainstem, via orexigenic and anorexigenic neuropeptides. Nesfatin-1, the amino-terminal fragment of nucleobindin 2, is a potent anorexigenic and anti-obesogenic neuropeptide, with widespread central distribution in rodents. In obese humans, our research group has recently reported reduced nesfatin-1 protein expression in the lateral hypothalamic area, a brain ...